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Zonisamide-13C2,15N
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zonisamide-13C2,15N图片
CAS NO:1188265-58-8
包装:5 mg
市场价:9878元

产品介绍

产品描述

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current.3 Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively.4,5 In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid or dihydroxyphenyl acetic acid , and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson's disease.6 Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.

Cas No.

1188265-58-8

分子式

C8H8N2O3S

分子量

215.2

别名

Zonisamide-13C2,15N;Zonisamide-13C2,15N

储存和溶解度

DMSO:Slightly soluble
Methanol:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years