Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

2305815-72-7

C111H211N59O26S

2820.33

R8-T198wt

20% acetonitrile / water:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years