Nemifitide acetate(173240-15-8 free base) 是一种合成的五肽抗抑郁药，具有快速起效的潜力。它是黑色素细胞抑制因子 (MIF) 的肽类似物。

Nemifitide acetate is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).

In-vitro studies indicate that both nemifitide and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].

Nemifitide (0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2]. Nemifitide (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].

TP1127L1

C35H47FN10O8

754.85

INN 00835 acetate;Nemifitide acetate(173240-15-8 free base)

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years