MS402 是一种新型 BD1 选择性 BET BrD 抑制剂，阻断 Th17 细胞分化并改善小鼠结肠炎，对BRD4(BD1)、BRD4(BD2)、BRD3(BD1)、BRD3(BD2)、BRD2(BD1)和BRD2(BD2)的Ki分别为 77 、718、110、200、83 和 240 nM。

MS402 is a novel BD1-selective BET BrD inhibitor.

MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation.?Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment.

1672684-68-2

C20H19ClN2O3

370.83

MS402

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years