Steroid sulfatase-IN-2 是一种有活性的类固醇硫酸酯酶 (STS) 抑制剂，IC50值为 109.5 nM。Steroid sulfatase-IN-2 可用于激素依赖性癌症的研究，如雌激素依赖性乳腺癌和子宫内膜癌。

Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC 50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer [1].

Steroid sulfatase-IN-2 (compound 1h, 0.001-10 μM, 1 h) inhibits STS in the lysate of JEG-3 cells, with an IC 50 value of 109.5 nM [1]. Steroid sulfatase-IN-2 (1-1 μM, 20 h) inhibits STS in a whole-cell assay against JEG-3 cells, with an IC 50 value of 13.6 nM [1]. Steroid sulfatase-IN-2 (0.01-100 μM, 5 days) shows dose-dependent antiproliferative activity against T-47D estrogen-dependent breast cancer cells [1]. Cell Viability Assay [1] Cell Line: T-47D cells Concentration: 0.01-100 μM Incubation Time: 5 days Result: Inhibited cell proliferation with an IC 50 value of 5.78 μM.

2413880-39-2

C17H22N2O4S

350.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years