Chloropyramine 是竞争性可逆 H1 受体拮抗剂。Chloropyramine 在乳腺癌中也具有抗肿瘤活性。Chloropyramine 可用于过敏性疾病的研究，如结膜炎和支气管哮喘。

Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma [1] [2].

Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines [1]. Western Blot Analysis [1] Cell Line: Breast cancer cell lines Concentration: 25 or 50 μM Incubation Time: 24 h Result: Increased SASH1 expression in breast cancer cell lines. Apoptosis Analysis [1] Cell Line: T47D, MDA-MB-231 and BT-54 cells Concentration: 50 μM Incubation Time: 48 h Result: Induced apoptosis in breast cancer cell lines.

Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats [2]. Animal Model: Rats [2] Dosage: 10 mg/kg Administration: Intraperitoneal Result: Reduced histamine-induced hypothermia.

59-32-5

C16H20ClN3

289.8

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years