ICA-121431 是强效的、广谱的电压门控钠通道阻滞剂，对人 Nav1.1 和 Nav1.3 亚型具有等效选择性，IC50分别为 13 nM 和 23 nM。它对Nav1.2 的抑制作用较弱，IC50为240 nM，对 Nav1.4、Nav1.6、抗TTX 的人 Nav1.5、Nav1.8 通道表现出大于 1000 倍的选择性，IC50>10 μM。

ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.

313254-51-2

C23H19N3O3S2

449.54

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl;ICA-121431

DMSO:44 mg/mL (97.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years