11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.

74841-69-3

C30H47N3O9S

625.78

11-trans Leukotriene C4;11-trans Leukotriene C4

DMSO:>50 mg/mL (per Ramki Iyer)
PBS (pH 7.2):>100 μg/mL (per Ramki Iyer)
Ethanol:>50 mg/mL (per Ramki Iyer)
DMF:>50 mg/mL (per Ramki Iyer)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years