Dacomitinib hydrate 是泛表皮生长因子受体家族酪氨酸激酶的高选择性第二代小分子抑制剂。 Dacomitinib 特异性且不可逆地结合并抑制人 EGFR 亚型，从而抑制表达 EGFR 的肿瘤细胞的增殖和诱导细胞凋亡。

Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

1042385-75-0

C24H27ClFN5O3

487.96

PF299804;PF00299804;:达克替尼一水合物;PF-00299804;PF-299804;PF 299804;PF 00299804;Dacomitinib hydrate

DMSO:55 mg/ml (112.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years