Oxotremorine M iodide 是 mAChR 的激动剂，可增强 NMDA 受体。

Oxotremorine M iodide is an agonist of mAChR and potentiates NMDA receptors.

Oxotremorine M iodide robustly elicits a phosphoinositide response (EC50 = 0.22 μM). Oxotremorine M iodide shows EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively[1]. Oxotremorine M iodide (0.1-30 μM) dose-dependently inhibits KCNQ2/3 currents[2].

In male Sprague-Dawley albino rats, Oxotremorine M iodide (0.5 mg/kg; s.c.) increases DA release in the medial prefrontal cortex without affecting the nucleus accumbens[4].

3854-04-4

C11H19IN2O

322.19

碘化氧化震颤素M;Oxotremorine methiodide;Oxotremorine M iodide

DMSO:100 mg/mL (310.4 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years