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Tazobactam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tazobactam图片
CAS NO:89786-04-9
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Tazobactam acid
YTR-830H
他唑巴坦
他唑巴坦酸
CL-298741
Tazobactamum
产品介绍
Tazobactam acid是一种具有抗菌活性的β-内酰胺酶抑制剂。

产品描述

Tazobactam is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

体内活性

Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. [1] Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. [2] Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. [3]Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. [4] Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. [5] Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. [6]

Cas No.

89786-04-9

分子式

C10H12N4O5S

分子量

300.29

别名

Tazobactam acid;YTR-830H;他唑巴坦;他唑巴坦酸;CL-298741;Tazobactamum;Tazobactam

储存和溶解度

DMSO:10 mM
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years