您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > α-(difluoromethyl)-DL-Arginine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
α-(difluoromethyl)-DL-Arginine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-(difluoromethyl)-DL-Arginine图片
CAS NO:69955-43-7
包装:100 mg
市场价:7214元

产品名称
RMI 71897
DFMA
产品介绍

产品描述

Bacteria synthesize the cellular growth factor putrescine through a number of pathways. One pathway involves the decarboxylation of arginine by arginine decarboxylase to produce agmatine, which is then degraded to putrescine. While important for various cellular processes (e.g., cell division, differentiation, environmental stress responses) in all living organisms, including plants, high levels of this polyamine can be toxic.[1] α-(difluoromethyl)-DL-Arginine (DFMA) is an enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 μM), P. aeruginosa, and K. pneumoniae.[2] At 0.01 mM, it has been shown to prevent the osmotic stress-induced increase in arginine decarboxylase activity and putrescine synthesis in oat leaf cells.[3],[4] DFMA can also reduce the growth of T. cruzi in mammalian host cells at a minimal concentration of 10 mM and prevent the growth of C. parvum in a T cell receptor alpha-deficient mouse model when combined with various polyamine analogs.[5],[6]

Cas No.

69955-43-7

分子式

C7H14F2N4O2

分子量

224.21

别名

RMI 71897;DFMA;α-(difluoromethyl)-DL-Arginine;α-(difluoromethyl)-DL-Arginine

储存和溶解度

PBS (pH 7.2):5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years