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Vps34-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vps34-IN-1图片
CAS NO:1383716-33-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
VPS34-IN1
产品介绍
Vps34-IN-1 是一种有效且高度选择性的 Vps34 抑制剂,可调节自噬,来自从专利WO2012085815A1,化合物实例16a,IC50为4nM。

产品描述

Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

体外活性

Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1].

Cas No.

1383716-33-3

分子式

C21H24ClN7O

分子量

425.92

别名

VPS34-IN1;Vps34-IN-1

储存和溶解度

H2O:<1 mgml
Ethanol:79 mg/mL (185.5 mM)
DMSO:79 mg/mL (185.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years