LC3-mHTT-IN-AN1 是一种 mHTT-LC3 接头化合物,可与突变亨廷顿蛋白 (mHTT) 和 LC3B 相互作用。 它将 mHTT 靶向自噬体以等位基因选择性方式降低培养的亨廷顿病小鼠神经元中的 mHTT 水平。
产品描述
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
体外活性
LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.
Cas No.
486443-73-6
分子式
C15H9Br2NO3
分子量
411.049
别名
LC3-mHTT-IN-AN1
储存和溶解度
DMSO:120 mg/ml(291.94 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years