MRS2179 tetrasodium hydrate 是一种竞争性P2Y1受体拮抗剂，对火鸡 P2Y1 受体的Kb值为 102 nM，pA2为 6.99。MRS2179 tetrasodium hydrate 对 P2Y1 的选择性高于 P2X1 (IC50=1.15 μM)、P2X3 (12.9 μM)、P2X2、P2X4、P2Y2、P2Y4 和 P2Y6 受体。MRS2179 tetrasodium hydrate 抑制血小板聚集。

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K b of 102 nM and a pA 2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC 50 =1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors [1] [2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation [3].

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time [3]. Animal Model: CL57BLr6 mice [3] Dosage: 50 mg/kg Administration: Injection into the jugular vein of mice Result: The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

C11H15N5Na4O10P2

576.21

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years