EzurPimtrostat hydrochloride (compound 2-3) 是一种口服有效的抗纤维化剂。EzurPimtrostat hydrochloride 能明显减轻 DEN (二乙基亚硝胺)肝硬化大鼠的肝纤维化。EzurPimtrostat hydrochloride 可用于纤维化、癌症、自噬和CTSB、CTSL 和 CTSD 相关的疾病研究。

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].

Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model [1].

1914148-73-4

C25H32Cl2N4

459.45

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years