ALK5-IN-31 (化合物 Ex-08) 是一种选择性的ALK-5抑制剂 (IC50≤10 nM;Ki)，能抑制TGF-β诱导的SMAD信号传导。ALK5-IN-31 有抑制体内肿瘤生长的潜力。ALK5-IN-31 可用于增殖性疾病，如癌症、纤维化疾病、系统性硬化症的研究。

ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor ( IC 50 ≤10 nM), inhibits TGF-β -induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis [1].

2785430-87-5

C23H23FN8

430.48

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years