Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4

26605-16-3

C27H48N6O9

600.7

Nocardamine

Ethanol:Soluble
Dichloromethane:Soluble
DMSO:Soluble
Methanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years