Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.

1020412-97-8

C31H35N3O5

529.63

Tie2 Inhibitor 7

Ethanol:1 mg/mL
DMF:14 mg/mL
DMSO:PBS (pH 7.2)(1:9):0.1 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years