5α-Pregnane-3β,6α-diol-20-one 是促进有丝分裂的 progesterone 代谢物，可于血清不足时雄性激素反应的前列腺素癌细胞中产生。

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone. It can be produced in starved androgen-responsive prostate cancer cells.

Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts [1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather dependent on 3β-HSD activity [2].

21853-11-2

C21H34O3

334.49

5α-Pregnane-3β,6α-diol-20-one

DMSO:100 mg/mL (298.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years