praeruptorin-C是中药前胡根中的有效成分前胡素C（Pra-C）可能具有神经保护作用。

Praeruptorin-C, an effective component in the root of Peucedanum praeruptorum dunn, a traditional Chinese medicine, may function in neuroprotection.

Treated 3-NP-injected mice with two different doses of praeruptorin C(Pra-C) (1.5 and 3.0mg/kg) for 3 days.?Motor behavior was tested using the open field test (OFT) and rotarod test, while psychiatric symptoms were tested using the forced swimming test (FST) and tail suspension test (TST).??Pra-C alleviated the motor deficits and depression-like behavior in the 3-NP-treated mice, and protected neurons from excitotoxicity.?Western blot analysis revealed that Pra-C upregulated BDNF, DARPP32, and huntingtin protein in the striatum of 3-NP mice.?Suggestd that Pra-C may have therapeutic potential with respect to the movement, psychiatric, and cognitive symptoms of HD[1].The protective effects of Pra-C on ovariectomized (OVX) mice bone are related to its inhibition of osteoclast formation and bone resorption[2].

83382-71-2

C24H28O7

428.5

praeruptorin C;白花前胡丙素;Praeruptorin-C

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years