Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective mu-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. Methylnaltrexone iodide has restricted ability to cross the blood-brain barrier.

At 2.0 mg/kg Methylnaltrexone iodide (morphine-induced male albino Hartley strain guinea pigs; injection), number of coughs returned to baseline value and nociception remained unaffected[2].

73232-53-8

C21H26INO4

483.34

Naltrexonium methiodide;碘化甲基纳曲酮； 碘甲纳曲酮;Methylnaltrexone iodide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years