生物活性
CZC-25146是一种高效、选择性的LRRK2抑制剂。CZC-25146可防止突变LRRK2对培养的啮齿动物和人神经元的损伤。
化学数据
| 目录号 | A13448 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 525.00 |
| Formula | C22H25FN6O4S.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1330003-04-7 |
| Synonyms | CZC-25146, CZC 25146, CZC25146 |
| SMILES | COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F.Cl |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.05 mL | 95.24 mL | 190.48 mL |
| 0.5 mM | 3.81 mL | 19.05 mL | 38.1 mL |
| 1 mM | 1.9 mL | 9.52 mL | 19.05 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
*The above data is based on the productmolecular weight 525.00. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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