Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.

144750-42-5

C15H15Cl2NO2S

344.26

Clopidogrel Carboxylic Acid (hydrochloride)

Ethanol:50 mg/mL
PBS (pH 7.2):10 mg/mL
DMSO:50 mg/mL
DMF:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years