2-Phenyl-2-(1-piperidinyl)propane 是一种具有可逆性、选择性的人CYP2B6抑制剂，其IC50为 5.1 μM，Ki为 5.6。它对 CYP2D6 、CYP3A 均有抑制作用，且IC50值分别为74 μM、200 μM。

2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine

2-Phenyl-2-(1-piperidinyl)propane (PPP) inactivated the 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats with a K(I) of 11 microM.?The 7-ethoxy-4-(trifluoromethyl)coumarin O-deethylation activity of purified rat liver P450 2B1 and expressed human P450 2B6 was inactivated by PPP in a reconstituted system containing NADPH-cytochrome P450 reductase and lipid[1]

92321-29-4

C14H21N

203.329

2-Phenyl-2-(1-piperidinyl)propane

DMSO:30mg/ml(99.8mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years