PPTN hydrochloride 是一种有效，高亲和力，竞争性和高选择性的P2Y14受体拮抗剂，KB为 434 pM。PPTN hydrochloride 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和抗免疫活性。

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity [1].

PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors [1]. PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC 50 s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM [1]. PPTN (10 μM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38 [2].

1992047-65-0

C29H25ClF3NO2

511.96

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years