N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

110429-36-2

C20H22FNO3

343.39

N-methyl Paroxetine

DMSO:20 mg/mL
DMF:PBS (pH 7) (1:10):0.09 mg/mL
Ethanol:20 mg/mL
DMF:33 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years