LP-922761 is an effective, selective, and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor (IC50: 4.8 nM and a cellular IC50: 7.6 nM). LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) (IC50: 24 nM). LP-922761 shows no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2, or GABAa receptors.

LP-922761 has a brain to plasma ratio of 0.007, in the mouse. It indicating that LP-922761 is essentially restricted to the peripheral compartment.

1454808-95-7

C21H26N6O3

410.47

LP-922761

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years