Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂，对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。

Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).

Difamilast exerts inhibitory effects on PDE2[1].

In relevant animal models of AD, Difamilast improves skin condition [3].

937782-05-3

C23H24F2N2O5

446.44

Difamilast

DMSO:100 mg/mL (223.99 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years