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Protectin D1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protectin D1图片
CAS NO:660430-03-5
包装:5 mg
市场价:7000元

产品介绍

产品描述

Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 μg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.

Cas No.

660430-03-5

分子式

C22H32O4

分子量

360.49

别名

Protectin D1

储存和溶解度

DMSO:50 mg/mL
PBS (pH 7.2):0.1 mg/mL
DMF:50 mg/mL
Ethanol:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years