PAT-1251 is a potent, selective, and oral lysyl oxidase-like 2 inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively. PAT-1251 is used in the research of fibrotic diseases. It also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively).

PAT-1251 displays are highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with<10% inhibition at 10 μM[1].

2007885-39-2

C18H17F4N3O3

399.34

PAT-1251

DMSO:130 mg/mL (325.54 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years