CAY10499 is a potent inhibitor of monoglyceride lipase (MGL) and human hormone-sensitive lipase. CAY10499 inhibited MGL-mediated 4-NPA hydrolysis with the IC 50 value of 0.5 ± 0.03 μM. CAY10499 fully inhibited [3H]-AEA hydrolysis by human recombinant FAAH with an IC50 of 76 nM. CAY10499 displaced only 25% and 20% of [3H]-CP-55940-specific binding to the CB1 and CB2 receptors, respectively [1]. CAY10499 potently inhibited the activity of human hormone-sensitive lipase with an IC50 of 90 nM for the recombinant human hormone-sensitive lipase enzyme [1][2].

T22637

C18H17N3O5

355.3

CAY10499

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years