CGP 20712 A (CGP 20712 mesylate) is a highly selective antagonist of β1-adrenoceptor (IC50: 0.7 nM). It shows ~10,000-fold selectivity over β2-adrenoceptors.

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM, or 1000 nM CGP 20712 A [2].

In 8-day-old rats, pretreatment with 5 mg/kg CGP 20712 A does not change the plasma ACTH response to insulin injection [3].

105737-62-0

C24H29F3N4O8S

590.57

CGP 20712 mesylate;CGP 20712 A

DMSO:100 mg/mL (169.33 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years