MIDOdrine hydrochloride 通过去甘氨酸反应转化为其活性代谢物desglymIDOdrine。DesglymIDOdrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 DesglymIDOdrine 在血脑屏障中的扩散很差，因此与对中枢神经系统的影响无关。 MIDOdrine Hydrochloride 是mIDOdrine的盐酸盐形式，是一种直接作用的前药和拟交感神经药，具有抗低血压特性。

Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier and is therefore not associated with effects on the central nervous system. Midodrine Hydrochloride is the hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties.

The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].

3092-17-9

C12H19ClN2O4

290.74

Pro-Amatine;盐酸米多君;Midodrine hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years