AMI-193 是一种有效和选择性的 5-HT2 和 D2 受体，对 5-HT2、D2 受体、5-HT1A、D1 受体和 5-HT1C 受体的 Kis 分别为 2、3、50、2530 和 4300 nM。 AMI-193 显示出抗精神病活性。

AMI-193 is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.

In adult male squirrel monkeys, AMI-193 (0.003 and 0.01 mg/kg; i.m.) decreases the response rate under a fixed-interval (FI) schedule of stimulus termination in a dose-dependent manner and under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). AMI-193 (0.003 and 0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine[2].

510-74-7

C22H26FN3O2

383.46

螺拉米特;Spiramide;AMI-193

DMSO:15 mg/mL (39.12 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years