DC-Chol is a cationic cholesterol derivative. [1] DC-Chol, as a component of lipoplexes with DOPE , has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.[2][3][4][5]

166023-21-8

C32H57ClN2O2

537.27

Cholesteryl 3β-N-(dimethylaminoethyl)carbamate;DC-Chol (hydrochloride);DC-Chol (hydrochloride)

DMSO:5 mg/mL
Methanol:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years