Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor.

Fosnetupitant shows a micromolar affinity for the 5-HT6 (pKi ～ 5.2) receptor and type L Ca2+ channels (pKi ～ 5.7). However, it does not bind all the other proteins investigated.

After i.v. injection in rats, Pronetupitant is rapidly and extensively converted to Netupitant.

1703748-89-3

C31H35F6N4O5P

688.6

Pronetupitant;Fosnetupitant

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years