Sultopride hydrochloride 是一种多巴胺D2受体的选择性拮抗剂。

Sultopride Hydrochloride is a selective dopamine D2 and D3 receptor antagonist.

Sultopride and sulpiride are both chemically similar benzamide derivatives and selective antagonists of dopamine D2 receptors.?However, these drugs differ in clinical properties.?We compared the effects of sultopride and sulpiride on dopamine turnover in rats following the administration of these drugs alone or in combination with apomorphine.?The administration of sultopride or sulpiride markedly accelerated dopamine turnover in the rat brain.?The increase in the level of dopamine metabolites in the striatum was more marked in the sultopride-treated rats.?Sulpiride affected the limbic dopamine receptors preferentially, whereas sultopride affected the striatal and the limbic dopamine receptors equally.?A low dose of apomorphine induced a reduction in the concentration of dopamine metabolites in the striatum and the nucleus accumbens by approximately 55%, but not in the medial prefrontal cortex.?Sultopride was more effective in preventing an apomorphine-induced reduction in dopamine metabolite levels.

23694-17-9

C17H27ClN2O4S

390.93

LIN-1418 hydrochloride;盐酸舒必利;盐酸舒托必利;Sultopride hydrochloride

DMSO:50 mg/mL (127.90 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years