NSI-189 Phosphate 是一种新型神经源性分子，具有多效性，包括临床前研究中证明的抗抑郁、促认知、突触和神经营养活性。其抗抑郁活性不依赖于单胺。

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.

NSI-189 actively stimulated remodeling of the stroke brain.?Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF.?These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke[1].

1270138-41-4

C22H33N4O5P

464.5

NSI 189 Phosphate;NSI-189磷酸盐;NSI189 Phosphate;NSI-189 Phosphate

DMSO:65 mg/ml (139.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years