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Befiradol hydrochloride(208110-64-9 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Befiradol hydrochloride(208110-64-9 free base)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NLX-112 hydrochloride
Befiradol hydrochloride
F 13640 hydrochloride
Befiradol hydrochloride (208110-64-9 free base)
产品介绍

产品描述

Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor.

体内活性

In microdialysis studies, Befiradol (0.04-0.63 mg/kg, i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC. Likewise, Befiradol (0.01-2.5 mg/kg, i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol in mPFC (1-1,000 μM) also increases extracellular DA in a concentration-dependent manner. Befiradol (F13640; NLX-112) reduces the activity of dorsal raphe serotonergic neurons at 0.2-18.2 μg/kg, i.v. (cumulative doses; ED50=0.69 μg/kg, i.v.) and increases the discharge rate of 80% of mPFC pyramidal neurons in the same dose range (ED50=0.62 μg/kg, i.v.). Both effects are reversed by the subsequent administration of the 5-HT1A receptor antagonist (±)WAY100635.

Cas No.

T10495

分子式

C20H23Cl2F2N3O

分子量

430.32

别名

NLX-112 hydrochloride;Befiradol hydrochloride;F 13640 hydrochloride;Befiradol hydrochloride (208110-64-9 free base)

储存和溶解度

DMSO:125 mg/mL (290.48 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years