GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8).

GR113808 (i.p.; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) displays a obviously enhance in the disease activity index which includes evaluation of weight loss, stool consistency, and presence of fecal blood [2].

144625-51-4

C19H27N3O4S

393.5

GR 113808

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years