SP-100030 是一种有效的 NF-Κb 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat和其他T细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1]. ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2].

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].

154563-54-9

C14H5ClF9N3O

437.65

SP 100030;SP100030;SP-100030

DMSO:45mg/mL (102.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years