SKF38393 HCl 是选择性的多巴胺 D1 受体激动剂，IC50=110 nM。

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]

SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

62717-42-4

C16H17NO2·HCl

291.77

(±)-SKF-38393 hydrochloride;SKF38393 HCl;SKF-38393A;SKF 38393 hydrochloride

H2O:<1 mgml
Ethanol:6 mg/mL(20.56 mM),warming
DMSO:54 mg/mL (185.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years