产品描述
RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R.
体内活性
RO27-3225 could have a protective role against multiple organ failure following the circulatory shock. RO27-3225 (0.012-0.048 mg/kg; i.v.; Wistar rats) treatment reverses haemorrhagic shock, reduces multiple organ damage and improves survival [2].
Cas No.
TP2154
分子式
C41H53F3N12O8
分子量
898.93
别名
RO27-3225 TFA;RO27-3225 TFA (274682-89-2 free base)
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years