6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).

62777-90-6

C20H34O5

354.487

6α-Prostaglandin I1;6α-Prostaglandin I1

DMF:>10 (from 6b-PGI1)
DMSO:>5 (from 6b-PGI1)
Ethanol:>20 mg/mL (from 6b-PGI1)
PBS (pH 7.2):>80 μg (from 6b-PGI1)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years