HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.

HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM.

430462-93-4

C25H25N3O3

415.48

HQ-415

DMSO:5.6 mg/mL (13.48 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years