Lodenafil 是一种有效的磷酸二酯酶 5 型(PDE5)抑制剂，可用于勃起功能障碍的研究。

Lodenafil is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)

Investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. Lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation[1].

Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization[1].

139755-85-4

C23H32N6O5S

504.61

Hydroxyhomosildenafil;羟基豪莫西地那非;Lodenafil

DMSO:250 mg/mL (495.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years