UNC926 抑制 L3MBTL1，还对 L3MBTL3 表现出低微摩尔亲和力。它抑制 3xMBT 结构域与 H4K20me1 的结合，可选择性和剂量依赖性地抑制 L3MBTL13xMBT-H4K20me1 相互作用。

UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC-926 has not an effect on the binding of 53BP1 to H4K20me1.

1184136-10-4

C16H21BrN2O

337.261

UNC 926 hydrochloride;UNC-926;UNC926

DMSO:37.4 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years