AChE/BChE/BACE-1-IN-2 (Compound 4o) 是一种具有口服活性的AChE、BChE和BACE-1抑制剂，对 hAChE、hBChE 和 hBACE-1 的IC50分别为 0.069、0.127 和 0.097 μM。AChE/BChE/BACE-1-IN-2 表现出良好的 PAS-AChE 结合能力、良好的脑通透性、潜在的 Aβ 聚集物的分解能力以及对 Aβ 诱导应激的神经保护作用。AChE/BChE/BACE-1-IN-2 具有显著的抗氧化潜能。

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC 50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential [1].

AChE/BChE/BACE-1-IN-2 (Compound 4o) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test [1].

1877000-20-8

C18H20F2N2

302.36

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years