CRT5 是一种吡嗪苯甲酰胺，对经 VEGF 处理的内皮细胞中的所有三种PKD亚型 (对 PKD1、PKD2 和 PKD3 的IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂，并且CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。

CRT5, a pyrazine benzamide, is a potent and selective PKD inhibitor. The VEGF-induced phosphorylation of three PKD substrates (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively), histone deacetylase 5, CREB (cAMP-response-element-binding protein), and HSP27 (heat-shock protein 27) at Ser82, is also inhibited by CRT5. CRT5 decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis[1].

1034297-58-9

C28H30N4O2

454.56

CRT5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years